Thursday, March 14, 2024

"Sound Science" Tipped to Benefit Industry

Science today parades as eternal Truth with its priests and disciples attacking all who challenge its mandates and statements of "fact." The premise that facts are never proven, only not dis-proven has been lost in the quasi-religion that now dominates our public policy.

Yet, decades of scholarship, whistle-blowing and news reporting have documented that science is not a homogeneous field with total consensus. Disagreement in science is what drives it forward. 

In addition to the current erasure of disagreement in facts and scientific-informed policy, today scientific findings are regularly subject to distortion and fraud that benefit individual scientists, their institutions and profit-oriented corporations.

Reviewing my notes today, I found this article:

Liza Gross. Seeding Doubt: How Self-Appointed Guardians of “Sound Science” Tip the Scales Toward Industry https://theintercept.com/2016/11/15/how-self-appointed-guardians-of-sound-science-tip-the-scales-toward-industry/

[EXCERPTED] Since the mid-1990s, numerous studies have shown that industry-funded research tends to favor its sponsors’ products. 

This effect has been documented in research financed by chemical, pharmaceutical, surgical, food, tobacco, and, we have learned most recently, sugar companies. 

In the 1960s, the sugar industry secretly paid scientists to minimize the role sugar plays in causing heart disease and blame saturated fat instead, according to a study published in the September issue of JAMA Internal Medicine. 

For decades, industry-funded research helped tobacco companies block regulations by undermining evidence that cigarettes kill. Precisely because of the very real risk of bias, prestigious scientific journals have long required researchers to disclose their sources of support. Journalists in pursuit of transparency have good reason to ask, “Who funded it?” 

President Eisenhower's farewell address specifically pointed to the risks of "big science" and this warning is even more relevant today I believe than when made:

Eisenhower’s Farewell Address. Reading copy of the speech [DDE’s Papers as President, Speech Series, Box 38, Final TV Talk (1); NAID #594599]. Dwight D. Eisenhower Presidential Library, Museum and Presidential Home, Abilene Kansas. Accessed October 6, 2015. Available: http://www.eisenhower.archives.gov/research/online_documents/farewell_address/Reading_Copy.pdf

 

RELATED POSTS

https://majiasblog.blogspot.com/2019/05/how-label-of-propaganda-is-used-by-nyt.html

https://majiasblog.blogspot.com/2017/11/radiation-is-safe-meme.html

https://majiasblog.blogspot.com/2016/05/false-narratives-in-media-echo-chambers.html

Majia's Blog: Public Relations is Propaganda

Majia's Blog: Engineering Consent Through Propaganda

Majia's Blog: Fake News and Naked Subjects

Majia's Blog: US Military Propaganda Program: Inform and Influence ...

Majia's Blog: Japan's Nuclear Utilities Spending on Public Relations

Monday, February 19, 2024

Marginalization, Denial and Censorship are NO ACCIDENT

 

During a Feb. 15 hearing by the Select Subcommittee on the Coronavirus Pandemic, Dr. Peter Marks FDA Director of the Center for Biologics Evaluation and Research avoided answering a direct question posed by the subcommittee regarding FDA's surveillance of the VAERS database for COVID-19 vaccine injuries. 

Given that the mRNA vaccines are a new technology first rolled out to the public during the COVID-19 pandemic, one would think that regulatory agencies would carefully monitor safety, particularly since these vaccines were "mandated" by the Biden Administration OSHA division and many corporations.

I know from personal experience how hazardous the mRNA technology can be, and I am truly outraged that evidence deemed negative is being ignored and/or censored (as "mal" or "dis" information) while criticism of the vaccines is literally being criminalized.

IGNORING EVIDENCE OF HARM

Dr. Marks referred the question about hazard surveillance to Dr. Daniel Jernigan, director of the National Center for Emerging and Zoonotic Infectious Diseases. Jernigan’s response not only lacks empirical support, but contradicts well documented research findings regarding mRNA vaccine risks:

Megan Redshaw 2/15/2024 Updated: 2/16/2024). US Officials Concede No Active Surveillance on Long-Term Effects of COVID-19 Vaccines. Epoch Times https://www.theepochtimes.com/health/us-officials-concede-no-active-surveillance-on-long-term-effects-of-covid-19-vaccines-5588199?utm_source=ref_share&utm_campaign=copy

“So with regard to myocarditis, we certainly have been monitoring the issue with various different data systems. I think the most recent data really demonstrates that you’re about eight times less likely to get myocarditis if you’re vaccinated compared to those that are unvaccinated,” Dr. Daniel Jernigan, director of the National Center for Emerging and Zoonotic Infectious Diseases at the CDC responded.

Apparently, Dr. Jernigan hasn’t read the following important study conducted in Israel that found myocarditis coincided with the vax rollouts, not the virus effects:

Sun, C.L.F., Jaffe, E. & Levi, R. Increased emergency cardiovascular events among under-40 population in Israel during vaccine rollout and third COVID-19 wave. Sci Rep 12, 6978 (2022). https://doi.org/10.1038/s41598-022-10928-z

Why would Dr. Jernigan state an uncertain finding of vaccine safety with such inappropriately exaggerated confidence and in so doing trivialize the well-documented risk of myocarditis in young men?

Note that he absolves responsibility for his assertion with the legal out of a faulty recollection through his “I think” caveat.

Notwithstanding his dissembling, what could be motivating this push to promote endless mRNA COVID-19 vaccine boosters and mRNA tech with no consideration of safety risks? What is going on here? Is this where we find ourselves?

Crutchfield P. Compulsory moral bioenhancement should be covert. Bioethics. 2019 Jan;33(1):112-121. doi: 10.1111/bioe.12496. Epub 2018 Aug 29. PMID: 30157295.

Or is the answer as simply as the reduction of human life into livestock for experimentation and exploitation?

DOCUMENTATION OF LACK OF TRANSPARENCY

"The C.D.C. Isn’t Publishing Large Portions of the Covid Data It Collects" The New York Times https://www.nytimes.com/2022/02/20/health/covid-cdc-data.html

SHUTTING DOWN INTERNAL DISSENT

Marty Makary April 3, 2022 FDA Shuts Out Its Own Experts in Authorizing Another Vaccine Booster. The Wall Street Journal, https://www.wsj.com/articles/fda-shuts-out-its-own-experts-in-authorizing-another-booster-covid-vaccine-pandemic-science-11649016728

Decisions like this only reinforce the perception that Covid policy is driven by groupthink and politics... Another committee member, Cody Meissner, agrees. Dr. Meissner, chief of pediatric infectious diseases at Tufts Children’s Hospital, told me last week that the fourth dose is “an unanswered scientific question for people with a normal immune system.” A third member of the committee, Paul Offit of the Children’s Hospital of Philadelphia, told the Atlantic that he advised his 20-something son to forgo the third shot, which the FDA recommends for everyone 12 and over. ... Two top FDA officials quit the agency in September complaining of undue pressure to authorize boosters. Marion Gruber, former director of the Office of Vaccine Research and Review, and her deputy, Philip Krause, later wrote about the lack of data to support a broad booster authorization. Hours after the FDA authorized the fourth dose, the Centers for Disease Control and Prevention gave its formal approval to the move—also without convening its external vaccine experts

AND then there are these articles, among others, voicing scientific and medical skepticism about the risk-benefit calculus being deployed by the FDA and WH:

Philip Krause and Luciana Borio March 28, 2022 You Likely Don’t Need a Fourth Covid Shot Unless you’re at high risk, the initial two vaccine doses are enough. The Wall Street Journal. https://www.wsj.com/articles/you-likely-dont-need-a-fourth-covid-shot-booster-dose-pfizer-moderna-vaccine-omicron-ba-2-ba2-11648498217

Dr. Krause is a consultant to the World Health Organization and was deputy director of FDA’s Office of Vaccines Research and Review, 2011-21. Dr. Borio is a senior fellow for global health at the Council on Foreign Relations and was director for medical and biodefense preparedness policy at the National Security Council, 2017-19

See also Constanze Kuhlmann, Carla Konstanze Mayer, Mathilda Claassen, Tongai Maponga, Wendy A Burgers,  Roanne Keeton, et al. (2022, January 18, 2022). Breakthrough infections with SARS-CoV-2 omicron despite mRNA vaccine booster dose. The Lancet.DOI:https://doi.org/10.1016/S0140-6736(22)00090-3

IGNORING CONTRARY EVIDENCE

Israeli study shows 4th shot of COVID-19 vaccine not able to block Omicron. (2022, January 17). MSN.Com https://www.msn.com/en-us/news/world/israeli-study-shows-4th-shot-of-covid-19-vaccine-not-able-to-block-omicron/ar-AASRT8Q

Lock, S. (2022, January 11). Repeated Covid boosters not viable strategy against new variants, WHO experts warn. https://www.theguardian.com/world/2022/jan/12/repeated-covid-boosters-not-viable-strategy-against-new-variants-who-experts-warn

CENSORED

This study cited here was algorithmically censored in 2021. I know because my posted comments online with this doi (article locator number) were censored. Here is the citation and the link to the press release for your reference:

SARS-CoV-2 Spike Protein Impairs Endothelial Function via Downregulation of ACE 2
Yuyang Lei , Jiao Zhang , Cara R. Schiavon, Ming He, Lili Chen, Hui Shen, Yichi Zhang, Qian Yin , Yoshitake Cho , Leonardo Andrade , Gerald S. Shadel , Mark Hepokoski, Ting Lei, Hongliang Wang, Jin hang, Jason X.-J. Yuan, Atul Malhotra, Uri Manor, Shengpeng Wang, Zu-Yi Yuan, John Y-J. Shyy Originally published31 Mar 2021https://doi.org/10.1161/CIRCRESAHA.121.318902Circulation Research. 2021;128:1323–1326

Other studies documented also that the spike protein, detached from the rest of the virus, elicits cell signalling in human cells, which "may promote pulmonary vacular remodeling and PAH [pulmonary arterial hypertension] as well as other cardiovascular complications":

Yuichiro J. Suzuki1,* and Sergiy G. Gychka SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Host Cells: Implications for Possible Consequences of COVID-19 Vaccines. Vaccines 2021, 9(1), 36; https://doi.org/10.3390/vaccines9010036
Here is an instructive excerpt from this research study:

3. SARS-CoV-2 Spike Protein Elicits Cell Signaling in Human Cells
It was found that the treatment of cultured primary human pulmonary artery smooth muscle cells (SMCs) or human pulmonary artery endothelial cells with the recombinant SARS-CoV-2 spike protein S1 subunit is sufficient to promote cell signaling without the rest of the viral components [21]. Furthermore, our analysis of the postmortem lung tissues of patients who died of COVID-19 has determined that these patients exhibited pulmonary vascular wall thickening, a hallmark of pulmonary arterial hypertension (PAH) [21]. Based on these results, we proposed that the SARS-CoV-2 spike protein (without the rest of the viral components) triggers cell signaling events that may promote pulmonary vascular remodeling and PAH as well as possibly other cardiovascular complications [21,22].

I suspect that the hundreds of instances of myocarditis and pericarditis investigated but then dismissed as “rare” by the FDA are the tip of the iceberg. See the FDA presentation here if it hasn't been censored already: https://www.fda.gov/media/150054/download 

One study provides an explanation of how  this might occur in their description of the circulation of the spike protein:

Circulating SARS-CoV-2 Vaccine Antigen Detected in the Plasma of mRNA-1273 Vaccine Recipients

Alana F. Ogata†1,2,3, Chi-An Cheng†1,2,3, Michaël Desjardins†3,4,5, Yasmeen Senussi1, Amy C. Sherman3,4, Megan Powell4, Lewis Novack4, Salena Von4, Xiaofang Li6, Lindsey R. Baden*3,4,6, David R. Walt*1,2,3. Downloaded from https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab465/6279075 by guest on 25 May 2021 

  

We have passed the rubicon so well described by G. Agamben, before he was censored and cancelled for challenging the governmental response to the pandemic.



Wednesday, January 31, 2024

The Terrifying & Frankensteinian Project to Bio-Engineer Your Proteins


Transfected mRNA in endothelial brain cells is Frankensteinian and raises very real risks for protein folding disorders given what we now know about "frameshifting" of protein production induced by the mRNA vaccines. (Note these are actually synthetic mRNA see my post here ).

Let us start by looking at the research article claiming to penetrate the blood-brain barrier using mRNA encased in lipid nanoparticles (LNPs):

Emily L. Han, Marshall S. Padilla, Rohan Palanki, Dongyoon Kim, Kaitlin Mrksich, Jacqueline J. Li, Sophia Tang, Il-Chul Yoon, and Michael J. Mitchell (2024). Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood–Brain Barrier Transfection and Crossing. Nano Lett. 2024, https://doi.org/10.1021/acs.nanolett.3c03509

Lipid nanoparticle (LNP)-mediated nucleic acid therapies, including mRNA protein replacement and gene editing therapies, hold great potential in treating neurological disorders including neurodegeneration, brain cancer, and stroke.
However, delivering LNPs across the blood–brain barrier (BBB) after systemic administration remains underexplored. In this work, we engineered a high-throughput screening transwell platform for the BBB (HTS-BBB), specifically optimized for screening mRNA LNPs.
Unlike most transwell assays, which only assess transport across an endothelial monolayer, HTS-BBB simultaneously measures LNP transport and mRNA transfection of the endothelial cells themselves.
We then use HTS-BBB to screen a library of 14 LNPs made with structurally diverse ionizable lipids and demonstrate it is predictive of in vivo performance by validating lead candidates for mRNA delivery to the mouse brain after intravenous injection. Going forward, this platform could be used to screen large libraries of brain-targeted LNPs for a range of protein replacement and gene editing applications.

  • Read Press Release here: https://penntoday.upenn.edu/news/bioengineers-brink-breaching-blood-brain-barrier
  • Also see publicity here:Tim Newcomb (2024, Jan 31). Scientists are about to break the blood-brain barrier- and maybe transform medicine. Popular Mechanics. https://www.popularmechanics.com/science/health/a46584155/blood-brain-barrier/

SO, what is being developed is a technique for bio-engineering how your brain cells produce proteins. NOW LET'S LOOK AT WHAT WE KNOW ABOUT FRAME-SHIFTING and explore the implications for how your body/brain produces proteins:

First, here is a press-release exploring frameshifting, or the glitching of protein production induced by the mRNA vaccines:

Pinkstone, Joe. (2023, December). Science Correspondent 6 December 2023 One in four who had Pfizer Covid jabs experienced unintended immune response https://www.telegraph.co.uk/news/2023/12/06/mrna-jabs-modena-pfizer-quarter-unintended-response/

mRNA vaccines were affected by the glitch but no adverse effects were created, Cambridge researchers say More than a quarter of people injected with mRNA Covid jabs suffered an unintended immune response created by a glitch in the way the vaccine was read by the body, a study has found. No adverse effects were created by the error, data show, but Cambridge scientists found such vaccines were not perfect and sometimes led to nonsense proteins being made instead of the desired Covid “spike”, which mimics infection and leads to antibody production. mRNA jabs, such as the ones created by Moderna and Pfizer, use a string of genetic material to tell the body to create a specific protein that safely imitates an infection. Research in the field, spanning decades, had been slow work. It often stalled because RNA itself is often attacked by the body as a foreign invader.

HERE IS THE RESEARCH STUDY upon which the press release is based:

Mulroney, T.E., Pöyry, T., Yam-Puc, J.C. et al. N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting. Nature (2023). https://doi.org/10.1038/s41586-023-06800-

In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). IVT mRNAs are transfected into target cells, where they are translated into recombinant protein, and the biological activity or immunogenicity of the encoded protein exerts an intended therapeutic effect1,2.

Modified ribonucleotides are commonly incorporated into therapeutic IVT mRNAs to decrease their innate immunogenicity3,4,5, but their effects on mRNA translation fidelity have not been fully explored. Here we demonstrate that incorporation of N1-methylpseudouridine into mRNA results in +1 ribosomal frameshifting in vitro and that cellular immunity in mice and humans to +1 frameshifted products from BNT162b2 vaccine mRNA translation occurs after vaccination.

The +1 ribosome frameshifting observed is probably a consequence of N1-methylpseudouridine-induced ribosome stalling during IVT mRNA translation, with frameshifting occurring at ribosome slippery sequences. However, we demonstrate that synonymous targeting of such slippery sequences provides an effective strategy to reduce the production of frameshifted products.

Overall, these data increase our understanding of how modified ribonucleotides affect the fidelity of mRNA translation, and although there are no adverse outcomes reported from mistranslation of mRNA-based SARS-CoV-2 vaccines in humans, these data highlight potential off-target effects for future mRNA-based therapeutics and demonstrate the requirement for sequence optimization.
BASICALLY, the process for engineering proteins is FULL OF ERRORS as the directions are subjected to frameshifting errors. So, mRNA produces MIS-FOLDED PROTEINS. 

I do not want misfolded proteins anywhere in my body, especially IN MY BRAIN.

IN OTHER NEWS - LEARN HOW SARS-CoV-2 viral proteins self-assemble into RNA that contribute to catastrophic auto-immune attacks:

SARS-CoV-2 viral fragments self-assemble into "new structures with double-stranded RNA, a special molecule essential for building proteins from DNA" and the resulting "hybrid complex of immune peptides and double-stranded RNA" produces a strong immune response.

California NanoSystems Institute JANUARY 29, 2024Viral protein fragments may unlock mystery behind serious COVID-19 outcomes https://medicalxpress.com/news/2024-01-viral-protein-fragments-mystery-covid.html

In a study appearing in the journal Proceedings of the National Academy of Sciences, a UCLA-led multidisciplinary research team explores one way that COVID-19 turns the immune system—which is crucial for keeping people alive—against the body itself, with potentially deadly results.

Using an artificial intelligence system they developed, the study authors scanned the entire collection of proteins produced by SARS-CoV-2 and then performed an exhaustive series of validation experiments. 

The scientists found that certain viral protein fragments, generated after the SARS-CoV-2 virus is broken down into pieces, can mimic a key component of the body's machinery for amplifying immune signals.

Their discoveries suggest that some of the most serious COVID-19 outcomes can result from these fragments overstimulating the immune system, thereby causing rampant inflammation in widely different contexts such as cytokine storms and lethal blood coagulation. 

…The research team found SARS-CoV-2 fragments can imitate innate immune peptides, a class of immune molecules that amplify signals to activate the body's natural defenses. Peptides are chains of amino acids like proteins, only shorter. 

These immune peptides can spontaneously assemble into new structures with double-stranded RNA, a special form of a molecule essential for building proteins from DNA, typically found in viral infections or released by dying cells.

The resultant hybrid complex of the immune peptides and double-stranded RNA kicks off a chain reaction that triggers an immune response. 

•More information: Yue Zhang et al, Viral afterlife: SARS-CoV-2 as a reservoir of immunomimetic peptides that reassemble into proinflammatory supramolecular complexes, Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2300644120. doi.org/10.1073/pnas.2300644120

 The spike proteins produced by the mRNA vaccines will produce same effects!

RELATED POSTS

http://majiasblog.blogspot.com/2023/09/hazards-of-mrna-vaccine-platform.html


http://majiasblog.blogspot.com/2022/05/mrna-vaccines-linked-to-higher-cardio.html

http://majiasblog.blogspot.com/2022/04/fda-shuts-out-its-own-experts-in.html

http://majiasblog.blogspot.com/2022/03/thanatopolitics-and-vaccine-apartheid.html

http://majiasblog.blogspot.com/2021/08/what-is-going-on-no-public-health.html

http://majiasblog.blogspot.com/2021/06/spike-protein-blues.html

http://majiasblog.blogspot.com/2021/06/approval-mandatory-vaccine-mandates-for.html 

 

http://majiasblog.blogspot.com/2022/05/mrna-vaccines-linked-to-higher-cardio.html

http://majiasblog.blogspot.com/2022/04/fda-shuts-out-its-own-experts-in.html

http://majiasblog.blogspot.com/2022/03/thanatopolitics-and-vaccine-apartheid.html

http://majiasblog.blogspot.com/2021/08/what-is-going-on-no-public-health.html

http://majiasblog.blogspot.com/2021/06/spike-protein-blues.html

http://majiasblog.blogspot.com/2021/06/approval-mandatory-vaccine-mandates-for.html